Myeloid neoplasms

Myeloid neoplasms arise from hematopoeitic stem cells and typically give rise to monoclonal proliferations that replace bone marrow. They can be classified into acute, chronic and myelodysplastic syndromes.

Acute myeloblastic leukemia

Here the neoplastic cells are blocked at some early stage of myeloid cell development. This leads to the formation of sheets of immature myeloid cells or blast cells.

Chronic myeloproliferative leukemia

In this disease, the neoplastic clone retains the capacity to undergo terminal differentiation but exhibits increased or dysregulated growth. This leads to an increase in one or more of the formed elements.

Myelodysplastic syndrome

Here terminal differention of myeloid cells appears but in a disordered and ineffective fashion leading to the appearance of dysplastic bone marrow precursors.